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Greg Coffey Selected Research

4- (3- (2H- 1,2,3- triazol- 2- yl)phenylamino)- 2- (2- aminocyclohexylamino)pyrimidine- 5- carboxamide

1/2017PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.
12/2013Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.
2/2013The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.

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Greg Coffey Research Topics

Disease

5Neoplasms (Cancer)
02/2017 - 02/2013
4Lymphoma (Lymphomas)
02/2017 - 12/2011
3Inflammation (Inflammations)
12/2014 - 02/2012
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
02/2017 - 02/2013
2Experimental Arthritis
01/2017 - 12/2014
2Rheumatoid Arthritis
12/2013 - 02/2012
1Autoimmune Diseases (Autoimmune Disease)
01/2017
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
12/2015
1Splenomegaly
12/2014
1B-Cell Leukemia (Leukemia, B Cell)
12/2014
1Non-Hodgkin Lymphoma (Lymphosarcoma)
02/2013

Drug/Important Bio-Agent (IBA)

4Syk KinaseIBA
01/2017 - 02/2012
34- (cyclopropylamino)- 2- ((4- (4- (ethylsulfonyl)piperazin- 1- yl)phenyl)amino)pyrimidine- 5- carboxamideIBA
02/2017 - 12/2014
34- (3- (2H- 1,2,3- triazol- 2- yl)phenylamino)- 2- (2- aminocyclohexylamino)pyrimidine- 5- carboxamideIBA
01/2017 - 02/2013
3Phosphotransferases (Kinase)IBA
12/2015 - 02/2013
1ibrutinibIBA
02/2017
1Pharmaceutical PreparationsIBA
12/2015
1B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA
12/2014
1AutoantibodiesIBA
12/2014
1Blood Proteins (Serum Proteins)IBA
12/2013
1Methotrexate (Mexate)FDA LinkGeneric
12/2013
1fludarabineIBA
02/2013
12- (2- aminocyclohexylamino)- 4- (m- tolylamino)pyrimidine- 5- carboxamideIBA
12/2011

Therapy/Procedure

1Oral Administration
02/2012
1Therapeutics
12/2011